Gengigel/Gengigel Prof Mechanism of Action

Pharmacology: Gengigel/Gengigel Prof is a long acting HMW hyaluronic acid, which, when applied, provides periodontal tissue/fluid balance with accelerated healing and repair functions by preventing the deficiency of natural gingival HMW hyaluronic acid and enhancing its effects.
Hyaluronic acid is a naturally occurring physiological constituent of connective tissue (especially in the gingival mucosa), where it performs anti-oedematous and tissue repair functions and does not develop any local or systemic pharmacological effect upon the mucosa.
Hyaluronic acid is extensively depolymerized and reduced to its basic subunit constituents by plaque bacterial enzyme action. The physico-chemical and macro-aggregating properties of hyaluronic acid helps to explain its anti-inflammatory properties. It is found in connective tissue throughout the body in a selective and specific manner. It is particularly concentrated in the outmost layers of healthy gingival tissue where it contributes to both the barrier function and tensile strength of the periodontal ligament. The presence of HMW hyaluronic acid is essential for the maintenance of the healthy gingival tissue.
In periodontal disease and other tissue traumas (inflammatory conditions, gingival pockets, wounds), the tissue requirement for hyaluronic acid increases considerably (by up to some 200% compared with the basal values); thus, demonstrating its specific role in regulating cell turnover and optimizing local tissue regeneration.
The deficiency in hyaluronic acid that arises under these conditions prevents the tissue from the following: Restoring the normal free water balance (as a consequence of which swelling and compression causes an increase in pain); activating the migration of fibrocytes (cells contributing to tissue healing) and as a consequence healing is delayed. Therefore, the lack of suitable HMW hyaluronic acid is responsible for the continuation of the inflammatory condition.
Studies in man show that the availability of exogenous hyaluronic acid of similar characteristics to that of the naturally occurring component helps to facilitate the natural tissue healing and recovery process.
Gengigel/Gengigel Prof provides maximum adhesion and thus, allows hyaluronic acid (which would otherwise be eliminated by constant salivary drainage) to remain in situ.